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Can I read Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population on EtoBox?
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population by David R. Bangsberg; Frederick M. Hecht; Edwin D. Charlebois; Andrew R. Zolopa; Mark Holodniy; Lewis Sheiner; Joshua D. Bamberger; Margaret A. Chesney; Andrew Moss is a Medicine article available to read on EtoBox.
What is Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population about?
Objective: To examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless and marginally housed people on protease inhibitor (PI) therapy. Design and setting: A cross-sectional analysis of subjects in an observational prospective cohort systematically sampled from free meal lines, homeless shelters and lowincome, single-room occupancy (SRO) hotels. Participants: Thirty-four HIV-infected people with a median of 12 months of PI therapy. Main outcomes: Adherence measured by periodic unannounced pill counts, electronic medication monitoring, and self-report; HIV RNA viral load; and HIV-1 genotypic changes associated with drug resistance. Results: Median adherence was 89, 73, and 67% by self-report, pill count, and electronic medication monitor, respectively. Thirty-eight per cent of the population had over 90% adherence by pill count. Depending on the measure, adherence explained 36±65% of the variation in concurrent HIV RNA levels. The three adherence measures were closely related. Of 20 genotyped patients who received a new reverse transcriptase inhibitor (RTI) when starting a PI, three had primary protease gene substitutions.
Who reads Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- David R. Bangsberg; Frederick M. Hecht; Edwin D. Charlebois; Andrew R. Zolopa; Mark Holodniy; Lewis Sheiner; Joshua D. Bamberger; Margaret A. Chesney; Andrew Moss
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)