Opening book details…
Can I read Effect of low dose oxandrolone and testosterone treatment on the pituitary‐testicular and GH axes in boys with constitutional delay of growth and puberty on EtoBox?
Effect of low dose oxandrolone and testosterone treatment on the pituitary‐testicular and GH axes in boys with constitutional delay of growth and puberty by E. C. Crowne; W. H. B. Wallace; C. Moore; R. Mitchell; W. H. Robertson; J. M. P. Holly; S. M. Shalet is a Medicine article available to read on EtoBox.
What is Effect of low dose oxandrolone and testosterone treatment on the pituitary‐testicular and GH axes in boys with constitutional delay of growth and puberty about?
OBJECTIVE To investigate the effect of low dose oxandrolone and testosterone on the pituitary‐ testicular and GH‐IGF‐I axes. DESIGN Prospective double‐blind placebo‐controlled trial. PATIENTS Sixteen boys with constitutional delay of growth and puberty (CDGP) with testicular volumes 4–6 ml were randomized to 3 months treatment: Group 1 (__n__ = 5), daily placebo: Group 2 (__n__ = 5), 2.5 mg oxandrolone daily or Group 3 (__n__ = 6), 50 mg testosterone monthly intramuscular injections with assessment (growth, pubertal development and overnight hormone profiles) at 0, 3, 6 and 12 months. MAIN OUTCOME MEASURES LH and GH profiles (15‐minute samples) were analysed by peak detection (Pulsar), Fourier transformation and autocorrelation. Testosterone levels were measured hourly and insulin, SHBG, IGF‐I, and IGFBP‐3 levels at 0800 h. Statistical analysis was by multivariate analysis of variance for repeated measures. RESULTS LH and testosterone parameters increased significantly with time in all 16 (LH AUC, __P__ < 0.0001; peak amplitude, __P__ = 0.02; number of peaks, __P__ = 0.02; testosterone AUC, __P__ = 0.02; morning testosterone, __P__ = 0.002). In Group 2, however, LH and testostero
Who reads Effect of low dose oxandrolone and testosterone treatment on the pituitary‐testicular and GH axes in boys with constitutional delay of growth and puberty?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- E. C. Crowne; W. H. B. Wallace; C. Moore; R. Mitchell; W. H. Robertson; J. M. P. Holly; S. M. Shalet
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)