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Can I read Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias on EtoBox?
Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias by Lima, Letícia Ferreira (author);Torres, André Quintanilha (author);Jardim, Rodrigo (author);Mesquita, Rafael Dias (author);Schama, Renata (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias about?
## Background Arthropoda, the most numerous and diverse metazoan phylum, has species in many habitats where they encounter various microorganisms and, as a result, mechanisms for pathogen recognition and elimination have evolved. The Toll pathway, involved in the innate immune system, was first described as part of the developmental pathway for dorsal-ventral differentiation in __Drosophila__. Its later discovery in vertebrates suggested that this system was extremely conserved. However, there is variation in presence/absence, copy number and sequence divergence in various genes along the pathway. As most studies have only focused on Diptera, for a comprehensive and accurate homology-based approach it is important to understand gene function in a number of different species and, in a group as diverse as insects, the use of species belonging to different taxonomic groups is essential. ## Results We evaluated the diversity of Toll pathway gene families in 39 Arthropod genomes, encompassing 13 different Insect Orders. Through computational methods, we shed some light into the evolution and functional annotation of protein families involved in the Toll pathway innate immune response. O
Who reads Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lima, Letícia Ferreira (author);Torres, André Quintanilha (author);Jardim, Rodrigo (author);Mesquita, Rafael Dias (author);Schama, Renata (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)