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Integrative Approach for Computationally Inferring Protein Domain Interactions by See-Kiong Ng; Zhuo Zhang; Soon-Heng Tan is a scholarly article available to read on EtoBox.

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{5kn9, 22han9, 500nhen9 }•11t.a-5tar.edu.59 A857RAC7 7he current need f0r h19h-thr0u9hput pr0te1n 1nteract10n detect10n ha5 re5u1ted 1n 1nteract10n data 6e1n9 9enerated en ma55e, u51n9 exper1menta1 meth0d5 5uch a5 yea5t-tw0-hy6r1d5 and pr0te1n ch1p5. 5uch data can 6e err0rfu1 and they 0ften d0 n0t pr0v1de ade4uate funct10na1 1nf0rmat10n f0r the detected 1nteract10n5; 1t 15 theref0re u5efu1 t0 deve10p an 1n 5111c0 appr0ach t0 further va11date and ann0tate the detected pr0te1n 1nteract10n5. 61ven that pr0te1n-pr0te1n 1nteract10n5 1nv01ve phy51ca1 1nteract10n5 6etween pr0te1n d0ma1n5, d0ma1n-d0ma1n 1nteract10n 1nf0rmat10n can 6e u5efu1 f0r va11dat1n9, ann0tat1n9, and even pred1ct1n9 pr0te1n 1nteract10n5. H0wever, 1ar9e-5ca1e exper1menta11y determ1ned d0ma1n-d0ma1n 1nteract10n data d0 n0t ex15t; a5 5uch, we de5cr16e an 1nte9rat1ve appr0ach t0 c0mputat10na11y der1ve putat1ve d0ma1n 1nteract10n5 fr0m mu1t1p1e data 50urce5, 1nc1ud1n9 r05etta 5t0ne 5e4uence5, pr0te1n 1nteract10n5, and pr0te1n c0mp1exe5. We 5h0w the u5efu1ne55 0f 5uch an 1nte9rat1ve appr0ach 6y app1y1n9 the der1ved d0ma1n 1nteract10n5 t0 pred1ct and va11date pr0te1n-pr0te1n 1nteract10n5.

Author
See-Kiong Ng; Zhuo Zhang; Soon-Heng Tan
Publisher
ACM
Published
2003
Language
EN

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