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Can I read The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute ⊕ Study on EtoBox?
The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute ⊕ Study by Daniel J Lips; Boukje Koebrugge; Gerrit Jan Liefers; Johannes C van de Linden; Vincent THBM Smit; Hans FM Pruijt; Hein Putter; Cornelis JH van de Velde; Koop Bosscha is a Medicine article available to read on EtoBox.
What is The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute ⊕ Study about?
## Background: The presence of lymph node metastases remains the most reliable prognostic predictor and the gold indicator for adjuvant treatment in colon cancer (cc). in spite of a potentially curative resection, 20 to 30% of cc patients testing negative for lymph node metastases (i.e. pn0) will subsequently develop locoregional and/or systemic metastases within 5 years. the presence of occult nodal isolated tumor cells (itcs) and/or micrometastases (mms) at the time of resection predisposes cc patients to high risk for disease recurrence. these pn0(micro+) patients harbouring occult micrometastases may benefit from adjuvant treatment. the purpose of the present study is to delineate the subset of pn0 patients with micrometastases (pn0(micro+)) and evaluate the benefits from adjuvant chemotherapy in pn0(micro+) cc patients. ## Methods/design: Enroute+ is an open label, multicenter, randomized controlled clinical trial. all cc patients (age above 18 years) without synchronous locoregional lymph node and/or systemic metastases (clinical stage i-ii disease) and operated upon with curative intent are eligible for inclusion. all resected specimens of patients are subject to an ex vivo
Who reads The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute ⊕ Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Daniel J Lips; Boukje Koebrugge; Gerrit Jan Liefers; Johannes C van de Linden; Vincent THBM Smit; Hans FM Pruijt; Hein Putter; Cornelis JH van de Velde; Koop Bosscha
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1471-2482)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)