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Antibacterial, anti-inflammatory and antioxidant activities of Mahanintangtong and its constituent herbs, a formula used in Thai traditional medicine for treating pharyngitis by Bhanuz Dechayont; Pathompong Phuaklee; Jitpisute Chunthorng-Orn; Thana Juckmeta; Onmanee Prajuabjinda; Kitrawee Jiraratsatit is a Medicine article available to read on EtoBox.
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## Background Mahanintangtong is listed in the Thailand’s National List of Essential Medicines (NLEM). It is used to treat non-specific fevers and illnesses such as pharyngitis and chickenpox. In this study, we investigated the biological activities of the different medicinal plants used in the Mahanintangtong formula. ## Methods The plant materials were extracted by maceration and decoction. Antimicrobial activity, assessed by disc diffusion method, the minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were compared with commercially available standard antibiotics. To elucidate the anti-inflammatory mechanisms, inhibition of nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) production was tested by Griess and ELISA techniques. Antioxidant activity was measured by ABTS and DPPH scavenging assays. ## Results The extracts with the best antimicrobial activities were carbonized __Tectona grandis__ showing against __Streptococcus pyogenes__, __Staphylococcus aureus__, Methicillin-resistant __Staphylococcus aureus__ (MRSA) and __Pseudomonas aeruginosa__. The ethanol extract of __Dracaena loureiroi__ wood exhibited the highest
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- Author
- Bhanuz Dechayont; Pathompong Phuaklee; Jitpisute Chunthorng-Orn; Thana Juckmeta; Onmanee Prajuabjinda; Kitrawee Jiraratsatit
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)