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Incorporation of Synthetic Water-soluble Curcumin Polymeric Drug Within Calcium Phosphate Cements for Bone Defect Repairing by Ying Zhang; Hailiang Xu; Jing Wang; Xiaochen Fan; Fang Tian; Zhiyuan Wang; Botao Lu; Weidong Wu; Youjun Liu; Yixiang Ai; Xiaohui Wang; Lei Zhu; Shuaijun Jia; Dingjun Hao is a Engineering article available to read on EtoBox.
What is Incorporation of Synthetic Water-soluble Curcumin Polymeric Drug Within Calcium Phosphate Cements for Bone Defect Repairing about?
Modified macroporous structures and active osteogenic substances are necessary to overcome the limited bone regeneration capacity and low degradability of self-curing calcium phosphate cement (CPC). Curcumin (CUR), which possesses strong osteogenic activity and poor aqueous solubility/bioavailability, esterifies the side chains in hyaluronic acid (HA) to form a water-soluble CUR-HA macromolecule. In this study, we incorporated the CUR-HA and glucose microparticles (GMPs) into the CPC powder to fabricate the CUR-HA/GMP/CPC composite, which not only retained the good injectability and mechanical strength of bone cements, but also significantly increased the cement porosity and sustained release property of CUR-HA __in vitro__. CUR-HA incorporation greatly improved the differentiation ability of bone marrow mesenchymal stem cells (BMSCs) to osteoblasts by activating the RUNX family transcription factor 2/fibroblast growth factor 18 (RUNX2/FGF18) signaling pathway, increasing the expression of osteocalcin and enhancing the alkaline phosphatase activity. In addition, __in vivo__ implantation of CUR-HA/GMP/CPC into femoral condyle defects dramatically accelerated the degradation rate of
Who reads Incorporation of Synthetic Water-soluble Curcumin Polymeric Drug Within Calcium Phosphate Cements for Bone Defect Repairing?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Ying Zhang; Hailiang Xu; Jing Wang; Xiaochen Fan; Fang Tian; Zhiyuan Wang; Botao Lu; Weidong Wu; Youjun Liu; Yixiang Ai; Xiaohui Wang; Lei Zhu; Shuaijun Jia; Dingjun Hao
- Publisher
- Elsevier
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)