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[British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021] Imaging by Radhakrishnan, Ashwin (author);Pickup, Luke (author);Price, Anna (author);Law, Jonathan (author);Fabritz, Larissa (author);Senior, Roxy (author);Steeds, Richard P. (author);Ferro, Charles (author);Townend, JN (author) is a nonfiction available to read on EtoBox.

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performed four hours post-injection with the amount of the three different tracers in the aortic arch quantified. Results LO1-huFab demonstrated in vivo targeting in LDLR-/mouse model with the ability to distinguish animals with and without disease (63.16 ± 12.64 pmol vs 23.92 ± 4.35 pmol, p=0.045, n=4 per group). Multiplexing with MMPSense and IntegriSense revealed LO1-huFab-750 to be the first probe to distinguish between disease states. Ex vivo fluorescence reflectance imaging validated the focal signal of LO1-huFab-750 observed in the aortic root and abdominal aorta. Rapid clearance of LO1-huFab-750 through the glomerular filtration system was evident through ex vivo quantification of fluorescence in the kidneys. Conclusion Site-specific near-infrared labeling of antibodies allowed for non-invasive imaging of atherosclerosis demonstrating its potential in identifying critical components of vulnerable plaques. These promising results have prompted the conjugation of LO1 antibody fragments with nanoparticles for targeted therapeutics of atherosclerosis.

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Author

Radhakrishnan, Ashwin (author);Pickup, Luke (author);Price, Anna (author);Law, Jonathan (author);Fabritz, Larissa (author);Senior, Roxy (author);Steeds, Richard P. (author);Ferro, Charles (author);Townend, JN (author)

Publisher

BMJ Publishing Group Ltd and British Cardiovascular Society

Published

2021

Language

EN

Category

nonfiction