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Functional Morphologic Changes in Female Sex Organs Induced by Exogenous Hormones by H. P. Zahradnik, Johanna Beyer (auth.), Professor Dr. Gisela Dallenbach-Hellweg (eds.) is a medicine available to read on EtoBox.

What is Functional Morphologic Changes in Female Sex Organs Induced by Exogenous Hormones about?

The synthetic estrogen diethylstilbestrol used between 1948 and 1970, mainly in the United States, as an antiabortive agent was found to be the cause for the appearance of vaginal clear-cell adenocarcinoma in around 350 young women born to mothers who were treated with this product during pregnancy because of the threat of abortion. The discovery of this etiologic relationship was made by a group of gynecologists and pathologists in Boston after seeing a clustering of the first eight cases within 3 years (Herbst et al. 1971). The pathogenetic mechanism of this cancer in women prenatally exposed to DES has since been understood by toxicologists as a transplacental cancerogenesis -the only one found as far in the human being. This theory is discussed in view of the fact that cancer developed only in a very low percentage of such prenatally exposed young women while a large majority presented with a benign teratogenic change: vaginal adenosis. To the pathologist the dysplastic transformation of glands of this atypical vaginal mucosa into adenocarcinoma in the pubertal woman suggests itself as a more likely pathogenesis. Thanks to the continuous investigation this hypothesis has now ob

Who reads Functional Morphologic Changes in Female Sex Organs Induced by Exogenous Hormones?

Author

H. P. Zahradnik, Johanna Beyer (auth.), Professor Dr. Gisela Dallenbach-Hellweg (eds.)

Publisher

Springer-Verlag Berlin Heidelberg

Published

1980

Language

EN

ISBN

9783642675706

Category

medicine

Subjects

Medical, Pathology, Gynecology & Obstetrics

Updated

2026-03-25