Can I read Glycolipids from the gut symbiont Bacteroides fragilis are agonists for natural killer T cells and induce their regulatory differentiation on EtoBox?

Glycolipids from the gut symbiont Bacteroides fragilis are agonists for natural killer T cells and induce their regulatory differentiation by Garth Cameron; Tram Nguyen; Marcin Ciula; Spencer J. Williams; Dale I. Godfrey is a Chemistry article available to read on EtoBox.

What is Glycolipids from the gut symbiont Bacteroides fragilis are agonists for natural killer T cells and induce their regulatory differentiation about?

Natural Killer T (NKT) cells are a lipid-antigen reactive T cell subset that is restricted to the antigen presenting molecule CD1d. They possess diverse functional properties that contribute to inflammatory and regulatory immune responses. The most studied lipid antigen target for these T cells is α-galactosylceramide (αGC). The commensal organism __Bacteroides fragilis__ (__B. fragilis__) produces several forms of αGC, but conflicting information exists about the influence of these lipids on NKT cells. Herein, we report the total synthesis of a major form of αGC from __B. fragilis__ (__Bf__ αGC), and several analogues thereof. We confirm the T cell receptor (TCR)-mediated recognition of these glycolipids by mouse and human NKT cells. Despite the natural structure of __Bf__ αGC containing lipid branching that limits potency, we demonstrate that __Bf__ αGC drives mouse NKT cells to proliferate and differentiate into producers of the immunoregulatory cytokine, interleukin-10 (IL-10). These __Bf__ αGC-experienced NKT cells display regulatory function by inhibiting the expansion of naïve NKT cells upon subsequent exposure to this antigen. Moreover, this regulatory activity impacts more

Who reads Glycolipids from the gut symbiont Bacteroides fragilis are agonists for natural killer T cells and induce their regulatory differentiation?

Author

Garth Cameron; Tram Nguyen; Marcin Ciula; Spencer J. Williams; Dale I. Godfrey

Publisher

Royal Society of Chemistry (RSC)

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)