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Antioxidants and an Inhibitor of Advanced Glycation Ameliorate Death of Retinal Microvascular Cells in Diabetic Retinopathy by Shigeru Yatoh; Masakazu Mizutani; Tomotaka Yokoo; Tadahiko Kozawa; Hirohito Sone; Hideo Toyoshima; Seiji Suzuki; Hitoshi Shimano; Yasushi Kawakami; Yukichi Okuda; Nobuhiro Yamada is a Medicine article available to read on EtoBox.
What is Antioxidants and an Inhibitor of Advanced Glycation Ameliorate Death of Retinal Microvascular Cells in Diabetic Retinopathy about?
## Abstract ## Background Pericyte ghosts and acellular capillaries are well known as early histological changes resulting from diabetic retinopathy. These histological changes mean that the cell death of retinal microvessels has accelerated. It was reported that apoptosis of retinal microvascular cells (RMCs) was increased in diabetic patients. Therefore, we investigated apoptosis of RMCs in Goto‐Kakizaki (GK) rats, a type 2 diabetic model, and involvement with antioxidants (a combination of vitamins C and E) or a novel inhibitor of advanced glycation, OPB‐9195. ## Methods GK rats were treated with the antioxidants combination or OPB‐9195 for 36 weeks. We obtained isolated preparations of the vascular network from their retinas by trypsin digestion. Apoptosis of retinal vascular cells was detected with terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) assay. ## Results We found that apoptosis of RMCs was increased in the diabetic GK rats. Furthermore, a combination of vitamins C and E and an advanced glycation end‐products inhibitor mostly inhibited this increased apoptosis. ## Conclusions We concluded that apoptosis of RMCs was a good marker that indic
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- Author
- Shigeru Yatoh; Masakazu Mizutani; Tomotaka Yokoo; Tadahiko Kozawa; Hirohito Sone; Hideo Toyoshima; Seiji Suzuki; Hitoshi Shimano; Yasushi Kawakami; Yukichi Okuda; Nobuhiro Yamada
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-7552)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)