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Can I read Lower expression of CD81 B-cell receptor in lymphoproliferative diseases associated with hepatitis C virus infection on EtoBox?
Lower expression of CD81 B-cell receptor in lymphoproliferative diseases associated with hepatitis C virus infection by P. Cacoub; M. Bourlière; P. Hausfater; F. Charlotte; H. Khiri; S. Toci; J. C. Piette; T. Poynard; P. Halfon is a Medicine article available to read on EtoBox.
What is Lower expression of CD81 B-cell receptor in lymphoproliferative diseases associated with hepatitis C virus infection about?
**summary.** Chronic hepatitis C virus (HCV) infection is frequently associated with type II mixed cryoglobulinaemia (MC), a benign lymphoproliferative disease (LPD). More recently, HCV has been implicated as a possible aetiologic factor of B‐cell non‐Hodgkin lymphoma (B‐NHL). CD81, a B‐cell surface receptor, has been proposed as a receptor for HCV binding and entry in circulating B cells. The stimulation of CD81 complex enables B cells to respond to lower concentrations of antigen and finally induces B‐cell proliferation. We studied the phenotypic expression of CD81, CD19 and CD5 on circulating B cells in HCV patients LPD‐positive or LPD‐negative. Sixty‐two patients were anti‐HCV antibody positive. Among HCV positive patients, 44 were HCV RNA positive with an histologically proven chronic active hepatitis of whom 10 had a B‐NHL, 14 an MC and 24 no extrahepatic manifestation. Eighteen patients were HCV RNA negative with evidence of resolved infection. A control group included 40 healthy subjects. Peripheral blood mononuclear cells (PBMC) were stained for surface expression of CD81, CD19 and CD5 using monoclonal antibodies, and were analyzed by flow cytometry. The percentage of PBM
Who reads Lower expression of CD81 B-cell receptor in lymphoproliferative diseases associated with hepatitis C virus infection?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- P. Cacoub; M. Bourlière; P. Hausfater; F. Charlotte; H. Khiri; S. Toci; J. C. Piette; T. Poynard; P. Halfon
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1352-0504)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)