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Exercise preconditioning inhibits doxorubicin-induced cardiotoxicity via YAP/STAT3 signaling by Wang, Chuan-Zhi (author);Guo, Heng-Zhi (author);Leng, Jing-Zhi (author);Liang, Zhi-De (author);Wang, Jing-Tai (author);Luo, Li-Jie (author);Wang, Shi-Qiang (author);Yuan, Yang (author) is a Medicine article available to read on EtoBox.

What is Exercise preconditioning inhibits doxorubicin-induced cardiotoxicity via YAP/STAT3 signaling about?

Doxorubicin (DOX) possesses strong anti-tumor effects but is limited by its irreversible cardiac toxicity. The relationship between exercise, a known enhancer of cardiovascular health, and DOX-induced cardiotoxicity has been a focus of recent research. Exercise has been suggested to mitigate DOX's cardiac harm by modulating the Yes-associated protein (YAP) and Signal transducer and activator of transcription 3 (STAT3) pathways, which are crucial in regulating cardiac cell functions and responses to damage. This study aimed to assess the protective role of exercise preconditioning against DOX-induced cardiac injury. We used Sprague–Dawley rats, divided into five groups (control, DOX, exercise preconditioning (EP), EP-DOX, and verteporfin + EP + DOX), to investigate the potential mechanisms. Our findings, including echocardiography, histological staining, Western blot, and q-PCR analysis, demonstrated that exercise preconditioning could alleviate DOX-induced cardiac dysfunction and structural damage. Notably, exercise preconditioning enhanced the nuclear localization and co-localization of YAP and STAT3. Our study suggests that exercise preconditioning may counteract DOX-induced card

Who reads Exercise preconditioning inhibits doxorubicin-induced cardiotoxicity via YAP/STAT3 signaling?

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Author
Wang, Chuan-Zhi (author);Guo, Heng-Zhi (author);Leng, Jing-Zhi (author);Liang, Zhi-De (author);Wang, Jing-Tai (author);Luo, Li-Jie (author);Wang, Shi-Qiang (author);Yuan, Yang (author)
Publisher
Elsevier BV
Published
2024
Language
EN
Field
Medicine (Physical Sciences)

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