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EMF signals and ion/ligand binding kinetics: prediction of bioeffective waveform parameters by A.A Pilla; D.J Muehsam; M.S Markov; B.F Sisken is a Engineering article available to read on EtoBox.

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The kinetics of an electromagnetic field EMF target pathway are used to estimate frequency windows for EMF bioeffects. Ionrligand binding is characterized via first order kinetics from which a specific electrical impedance can be derived. The resistancercapacitance properties of the binding pathway impedance, determined by the kinetics of the rate-determining step, define the frequency range over which the target pathway is most sensitive to external EMF. Applied signals may thus be configured such that their spectral content closely matches that of the target, using evaluation of the signal to thermal noise ratio to optimize waveform parameters. Ž . Using the approach proposed in this study, a pulsed radio frequency PRF waveform, currently employed clinically for soft tissue repair, was retuned by modulation of burst duration, producing significant bioeffects at substantially reduced signal amplitude. Application is made to Ca 2q rCalmodulin-dependent myosin phosphorylation, for which the binding time constants may be estimated from reported kinetics, neurite outgrowth from embryonic chick dorsal root explants and bone repair in a fracture model. The results showed that the retune

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Author

A.A Pilla; D.J Muehsam; M.S Markov; B.F Sisken

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-5394)

Published

1999

Language

EN

Field

Engineering (Physical Sciences)