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The changing face of HIV‐associated lymphoma: what can we learn about optimal therapy inl the post highly active antiretroviral therapy era? by Alison Clayton; Tariq Mughal is a Medicine article available to read on EtoBox.

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## Abstract Epidemiological data indicate that the risk of developing non‐Hodgkin lymphoma (NHL) in HIV positive individuals is related to age and CD4 count (i.e. degree of immunosuppression). The prognosis of patients with HIV‐NHL has been shown to be linked to several features including age, stage, modified IPI, prior AIDS diagnosis, CD4 count, immunoblastic pathology, LDH, and HAART use. These features are, as would be expected, a mixture of prognostic factors relating to both the HIV, and to the NHL. Population studies indicate that the incidence of associated (HIV‐NHL) may be reducing with the advent of HAART, although not all studies concur. However, most population‐based studies have not as yet shown a significant improvement in the survival of patients with HIV‐NHL with HAART. The optimal chemotherapy for these patients is unknown, although it is generally accepted that CNS prophylaxis is mandatory. There is currently no good evidence of any survival benefit with increased dose intensity from large RCT. However, it must be borne in mind that the large randomised studies comparing differing dose intensities were undertaken before the advent of effective HAART. There is some

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Author

Alison Clayton; Tariq Mughal

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0278-0232)

Published

2004

Language

EN

Field

Medicine (Health Sciences)