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Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset by Quah, S.K.L; McIver, L.; Roberts, A.C.; Santangelo, A.M. is a Neuroscience article available to read on EtoBox.

What is Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset about?

High trait anxiety is associated with altered activity across emotion regulation circuitry and a higher risk of developing anxiety disorders and depression. This circuitry is extensively modulated by serotonin. Here, to understand why some people may be more vulnerable to developing affective disorders, we investigated whether serotonin-related gene expression across the brain's emotion regulation circuitry may underlie individual differences in trait anxiety using the common marmoset (, mixed sexes) as a model. First, we assessed the association of region-specific expression of the serotonin transporter () and serotonin receptor (, , ) genes with anxiety-like behavior; and second, we investigated their causal role in two key features of the high trait anxious phenotype: high responsivity to anxiety-provoking stimuli and an exaggerated conditioned threat response. While the expression of the serotonin receptors did not show a significant relationship with anxiety-like behavior in any of the targeted brain regions, serotonin transporter expression, specifically within the right ventrolateral prefrontal cortex (vlPFC) and most strongly in the right amygdala, was associated positively

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Author

Quah, S.K.L; McIver, L.; Roberts, A.C.; Santangelo, A.M.

Publisher

Society for Neuroscience (ISSN 0270-6474)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)