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TIGIT and PD-1 may serve as potential prognostic biomarkers for gastric cancer by Danhua Xu; Enhao Zhao; Chunchao Zhu; Wenyi Zhao; Chaojie Wang; Zizhen Zhang; Gang Zhao is a Immunology and Microbiology article available to read on EtoBox.

What is TIGIT and PD-1 may serve as potential prognostic biomarkers for gastric cancer about?

Gastric Cancer (GC) is the fifth leading cause of cancer-related death in the world, and in urgent need of specific therapeutic targets to acquire prominent effectiveness. T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) and programmed cell death protein 1 (PD-1) are identified to be abnormally overexpressed in various types of cancers including GC. This study aimed to investigate whether TIGIT and PD-1 could serve as potential prognostic biomarkers for GC. Firstly, TCGA GC dataset analysis and correlation analysis were utilized to inspect the relationship between expression of TIGIT, PD-1 and CD8 + T cells in GC and adjacent normal tissues. Then, flow cytometry was used to verify the data after collecting the peripheral blood, GC and adjacent normal tissues from 150 GC patients. Lastly, quantitative RT-PCR was performed to detect the expression of CD155, CD113, CD112 and TIGIT in six human GC cell lines and 631 GC patients in KM Plotter Database to conduct prognostic analysis. As results, we found that TIGIT and PD-1 were upregulated in GC tissues with high CD8 + T cells infiltration, while correlation analysis indicated they were in h

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Author

Danhua Xu; Enhao Zhao; Chunchao Zhu; Wenyi Zhao; Chaojie Wang; Zizhen Zhang; Gang Zhao

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0171-2985)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)