Can I read Kappa Opioid Receptor Activation Blocks Progressive Neurodegeneration After Kainic Acid Injection on EtoBox?

Kappa Opioid Receptor Activation Blocks Progressive Neurodegeneration After Kainic Acid Injection by Eduard Schunk; Cornelia Aigner; Nadia Stefanova; Gregor Wenning; Herbert Herzog; Christoph Schwarzer is a Neuroscience article available to read on EtoBox.

What is Kappa Opioid Receptor Activation Blocks Progressive Neurodegeneration After Kainic Acid Injection about?

## Abstract We recently demonstrated that endogenous prodynorphin‐derived peptides mediate anticonvulsant, antiepileptogenic and neuroprotective effects via kappa opioid receptors (KOP). Here we show acute and delayed neurodegeneration and its pharmacology after local kainic acid injection in prodynorphin knockout and wild‐type mice and neuroprotective effect(s) of KOP activation in wild‐type mice. Prodynorphin knockout and wild‐type mice were injected with kainic acid (3 nmoles in 50 nl saline) into the stratum radiatum of CA1 of the right dorsal hippocampus. Knockout mice displayed significantly more neurodegeneration of pyramidal cells and interneurons than wild‐type mice 2 days after treatment. This phenotype could be mimicked in wild‐type animals by treatment with the KOP antagonist GNTI and rescued in knockout animals by the KOP agonist U‐50488. Minor differences in neurodegeneration remained 3 weeks after treatment, mostly because of higher progressive neurodegeneration in wild‐type mice compared with prodynorphin‐deficient animals. In wild‐type mice progressive neurodegeneration, but not acute neuronal loss, could be mostly blocked by U‐50488 treatment. Our data suggest tha

Who reads Kappa Opioid Receptor Activation Blocks Progressive Neurodegeneration After Kainic Acid Injection?

Author

Eduard Schunk; Cornelia Aigner; Nadia Stefanova; Gregor Wenning; Herbert Herzog; Christoph Schwarzer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2010

Language

EN

Field

Neuroscience (Life Sciences)