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What is Nitric Oxide Synthase in Hepatic Encephalopathy about?
The study investigated the effects of inhibiting different nitric oxide synthase isoforms on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. Chronic inhibition of total nitric oxide synthase using L-NAME worsened liver damage, motor function, and survival compared to inhibiting only inducible nitric oxide synthase or saline treatment. This suggests constitutive nitric oxide synthase plays a protective role in this disease model.
- Author
- attamira95
- Language
- EN