Can I read Role of Mitochondrial Dysfunction and Oxidative Stress in Sensorineural Hearing Loss on EtoBox?

Role of Mitochondrial Dysfunction and Oxidative Stress in Sensorineural Hearing Loss by Winston J.T. Tan; Lei Song is a Neuroscience article available to read on EtoBox.

What is Role of Mitochondrial Dysfunction and Oxidative Stress in Sensorineural Hearing Loss about?

Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological mechanisms underlying SNHL remain unclear, an overwhelming body of evidence implicates mitochondrial dysfunction and oxidative stress playing a central etiological role. With its high metabolic demands, the cochlea, particularly the sensory hair cells, stria vascularis, and spiral ganglion neurons, is vulnerable to the damaging effects of mitochondrial reactive oxygen species (ROS). Mitochondrial dysfunction and consequent oxidative stress in cochlear cells can be caused by inherited mitochondrial DNA (mtDNA) mutations (hereditary hearing loss and aminoglycoside-induced ototoxicity), accumulation of acquired mtDNA mutations with age (age-related hearing loss), mitochondrial overdrive and calcium dysregulation (noise-induced hearing loss and cisplatin-induced ototoxicity), or accumulation of ototoxic drugs within hair cell mitochondria (druginduced hearing loss). In this review, we provide an overview of our current knowledge on the role of mitochondrial dysfunction and oxidative stress in the development o

Who reads Role of Mitochondrial Dysfunction and Oxidative Stress in Sensorineural Hearing Loss?

Author

Winston J.T. Tan; Lei Song

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)