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This study presents a systematic review and meta-analysis of the effects of benzodiazepines and specific serotonin reuptake inhibitors (SSRIs) in the mouse defensive marble burying test (MBT), highlighting the need for evaluating the validity and reproducibility of animal models in anxiety disorder research. The analysis included 73 experiments for benzodiazepines and 47 for SSRIs, revealing significant effects of both drug classes on reducing anxiety-like behavior, with a notable dose-response relationship

Author

Vivian C. Monteiro Pereira

Language

EN