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Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the her-2/neu oncogene by Beppino C. Giovanella; Dana M. Vardeman; Leo J. Williams; D. Jane Taylor; Peter D. De Ipolyi; Pierre J. Greeff; John S. Stehlin; Axel Ullrich; Relda Cailleau; Dennis J. Slamon; JR. Howard E. Gary is a Medicine article available to read on EtoBox.

What is Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the her-2/neu oncogene about?

## Abstract Four hundred and thirty‐three human breast carcinomas and 23 cell lines derived from human breast carcinomas were heterotransplanted in nude mice. Twenty‐eight tumors and 13 cell lines took and could be serially transplanted. Their human origin was established by isozyme analysis performed on successive passages. Sixteen primary infiltrating duct‐cell carcinomas (PIDC) took, from a total of 262 transplanted (6.1%). This is in striking contrast to the >50% rate of takes of most major cancers of epithelial origin. All 16 PIDC growing in nude mice were highly cellular and lacked desmoplastic hyperplasia. The clinical prognosis of the PIDC patients whose tumors were successfully transplanted was poor. Ten of 16 (63%) died of their disease within 3 years, compared to only 49 (20%) of the 246 PIDC patients whose tumors did not take in nude mice. This could not be attributed to later stage disease of the tumors that took, because only 15% of these patients had 4 or more positive axillary lymph nodes as opposed to 28% of the patients whose tumors did not take. Sixty‐four percent of the breast carcinomas growing in nude mice exhibited amplification of the HER‐2/__neu__ oncogene

Who reads Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the her-2/neu oncogene?

Author

Beppino C. Giovanella; Dana M. Vardeman; Leo J. Williams; D. Jane Taylor; Peter D. De Ipolyi; Pierre J. Greeff; John S. Stehlin; Axel Ullrich; Relda Cailleau; Dennis J. Slamon; JR. Howard E. Gary

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1991

Language

FR

ISBN

9782910470111

Field

Medicine (Health Sciences)