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Glutamate and prostaglandin E~2~ in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis by Gerd M. Flodgren; Albert G. Crenshaw; Häkan Alfredson; Martin Fahlström; Fredrik B. Hellström; Lars Bronemo; Mats Djupsjöbacka is a Medicine article available to read on EtoBox.
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## Abstract Much is still unknown concerning the mechanisms underlying the development of chronic muscle pain. The presence and magnitude of inflammatory substances and neurotransmitters in chronic painful conditions is not clear. The aims of the present study were to determine, with the use of microdialysis, the interstitial concentrations and the equilibration times for PGE~2~ and glutamate in the trapezius muscles of nine female subjects with chronic muscle pain, and nine pain‐free age‐matched controls. A microdialysis probe was implanted in the upper part of the trapezius muscle and perfused with Ringer‐acetate solution at a flow rate of 0.3 μL/min. Samples were obtained every 30 min, during a 4‐h rest period. At equilibration, the mean concentrations (−SE) of PGE~2~ were 0.71 (−0.11) ng/mL for the pain‐group and 0.97 (−0.35) ng/mL for the controls. For glutamate the mean concentrations for the pain‐group were 66.3 (−13.3) μmol/L and 60.6 (−22.9) μmol/L for the controls. For the pain group and the control group, respectively, equilibration for PGE~2~ was reached at 180 and 150 min, and for glutamate at 150 and 120 min. The present study showed no differences between groups in t
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- Author
- Gerd M. Flodgren; Albert G. Crenshaw; Häkan Alfredson; Martin Fahlström; Fredrik B. Hellström; Lars Bronemo; Mats Djupsjöbacka
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)