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Sensitive Magnetic Particle Imaging of Haemoglobin Degradation for the Detection and Monitoring of Intraplaque Haemorrhage in Atherosclerosis by Wei Tong; Yingqian Zhang; Hui Hui; Xin Feng; Bin Ning; Tengfei Yu; Wei Wang; Yaxin Shang; Guanghao Zhang; Suhui Zhang; Feng Tian; Wen He; Yundai Chen; Jie Tian is a Medicine article available to read on EtoBox.
What is Sensitive Magnetic Particle Imaging of Haemoglobin Degradation for the Detection and Monitoring of Intraplaque Haemorrhage in Atherosclerosis about?
## Summary ## Background Intraplaque haemorrhage (IPH) drives atherosclerosis progression and is a key imaging biomarker of unstable plaques. Non-invasive and sensitive monitoring of IPH is challenging due to the compositional complexity and dynamic nature of atherosclerotic plaques. Magnetic particle imaging (MPI) is a highly sensitive, radiation-free, and no-tissue-background tomographic technique that detects superparamagnetic nanoparticles. Thus, we aimed to investigate whether MPI can __in vivo__ detect and monitor IPH. ## Methods Thirty human carotid endarterectomy samples were collected and scanned with MPI. The tandem stenosis (TS) model was employed to establish unstable plaques with IPH in ApoE^−/−^ mice. MPI and 7 T T1-weighted magnetic resonance imaging (MRI) were performed on TS ApoE^−/−^ mice. Plaque specimens were analyzed histologically. ## Findings Human carotid endarterectomy samples exhibited endogenous MPI signals, which histologically colocalized with IPH. __In vitro__ experiments identified haemosiderin, a haemoglobin degradation product, as a potential source of MPI signals. Longitudinal MPI of TS ApoE^−/−^ mice detected IPH at unstable plaques, of which MPI
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- Author
- Wei Tong; Yingqian Zhang; Hui Hui; Xin Feng; Bin Ning; Tengfei Yu; Wei Wang; Yaxin Shang; Guanghao Zhang; Suhui Zhang; Feng Tian; Wen He; Yundai Chen; Jie Tian
- Publisher
- Elsevier
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)