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Novel Method of Calculating Adjusted Antibiotic Use by Microbiological Burden by Hana R. Winders; Majdi N. Al-Hasan; Bruce M. Jones; Darrell T. Childress; Kayla R. Stover; Benjamin B. Britt; Elias B. Chahine; Suetping Lau; Pamela D. Andrews; Shauna Jacobson Junco; Rebekah H. Wrenn; Brad J. Crane; Jordan R. Wong; Megan M. Seddon; Christopher M. Bland; Shawn H. MacVane; Geneen M. Gibson; P. Brandon Bookstaver is a Medicine article available to read on EtoBox.

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## Abstract ## Objective: To determine the usefulness of adjusting antibiotic use (AU) by prevalence of bacterial isolates as an alternative method for risk adjustment beyond hospital characteristics. ## Design: Retrospective, observational, cross-sectional study. ## Setting: Hospitals in the southeastern United States. ## Methods: AU in days of therapy per 1,000 patient days and microbiologic data from 2015 and 2016 were collected from 26 hospitals. The prevalences of Pseudomonas aeruginosa, extended-spectrum β-lactamase (ESBL)–producing bacteria, methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant enterococci (VRE) were calculated and compared to the average prevalence of all hospitals in the network. This proportion was used to calculate the adjusted AU (a-AU) for various categories of antimicrobials. For example, a-AU of antipseudomonal β-lactams (APBL) was the AU of APBL divided by (prevalence of P. aeruginosa at that hospital divided by the average prevalence of P. aeruginosa). Hospitals were categorized by bed size and ranked by AU and a-AU, and the rankings were compared. ## Results: Most hospitals in 2015 and 2016, respectively, moved ≥2 positions

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Author

Hana R. Winders; Majdi N. Al-Hasan; Bruce M. Jones; Darrell T. Childress; Kayla R. Stover; Benjamin B. Britt; Elias B. Chahine; Suetping Lau; Pamela D. Andrews; Shauna Jacobson Junco; Rebekah H. Wrenn; Brad J. Crane; Jordan R. Wong; Megan M. Seddon; Christopher M. Bland; Shawn H. MacVane; Geneen M. Gibson; P. Brandon Bookstaver

Publisher

Cambridge University Press (CUP)

Published

2021

Language

EN

Field

Medicine (Health Sciences)