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## a b s t r a c t Cryosurgery is particularly suitable for the treatment of unresectable liver tumors. However, a major bottleneck is encountered during the treatment of large-sized irregularly shaped tumors. Large and complex liver tumors have varying degree of shape irregularity. Adopting a multiprobe freezing model, simulations for an irregularly shaped liver tumor were conducted. The model, validated with both invitro data from an experimental setup, showed good agreement of up to 5.8%. The chosen mathematical treatment and simulation technique permit the study of employing multiple cryoprobes to destroy cancer cells in irregularly shaped tumors. Results from our study indicated that multiple cryoprobes can be strategically positioned to form ice-fronts with various contours that adhere to the shape and size of the tumor. The amount of cell-deaths within the tumor after the À 50 1C ice-front can be quantitatively calculated to determine the efficacy of different multiprobe arrangements in order to maximize cell destruction. The paper also underlines a piecewise approach of using several cryoprobes to quickly 'sculpt' the desired shape of the ice-front based on the physical mor

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Author

K.J. Chua

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0010-4825)

Published

2011

Language

EN

Field

Medicine (Physical Sciences)