Opening book details…
Can I read Matrix Metalloproteinase-10 Protects Against Acute Kidney Injury by Augmenting Epidermal Growth Factor Receptor Signaling on EtoBox?
Matrix Metalloproteinase-10 Protects Against Acute Kidney Injury by Augmenting Epidermal Growth Factor Receptor Signaling by Hu, Chengxiao (author);Zuo, Yangyang (author);Ren, Qian (author);Sun, Xiaoli (author);Zhou, Shan (author);Liao, Jinlin (author);Hong, Xue (author);Miao, Jinhua (author);Zhou, Lili (author);Liu, Youhua (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Matrix Metalloproteinase-10 Protects Against Acute Kidney Injury by Augmenting Epidermal Growth Factor Receptor Signaling about?
## Abstract Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis, cell proliferation, and tissue remodeling. However, the role of MMP-10 in the pathogenesis of acute kidney injury (AKI) is unknown. In this study, we show that MMP-10 was upregulated in the kidneys and predominantly localized in the tubular epithelium in various models of AKI induced by ischemia/reperfusion (IR) or cisplatin. Overexpression of exogenous MMP-10 ameliorated AKI, manifested by decreased serum creatinine, blood urea nitrogen, tubular injury and apoptosis, and increased tubular regeneration. Conversely, knockdown of endogenous MMP-10 expression aggravated kidney injury. Interestingly, alleviation of AKI by MMP-10 in vivo was associated with the activation of epidermal growth factor receptor (EGFR) and its downstream AKT and extracellular signal-regulated kinase-1 and 2 (ERK1/2) signaling. Blockade of EGFR signaling by erlotinib abolished the MMP-10-mediated renal protection after AKI. In vitro, MMP-10 potentiated EGFR activation and protected kidney tubular cells against apoptosis induced by hypoxia/reoxygenatio
Who reads Matrix Metalloproteinase-10 Protects Against Acute Kidney Injury by Augmenting Epidermal Growth Factor Receptor Signaling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hu, Chengxiao (author);Zuo, Yangyang (author);Ren, Qian (author);Sun, Xiaoli (author);Zhou, Shan (author);Liao, Jinlin (author);Hong, Xue (author);Miao, Jinhua (author);Zhou, Lili (author);Liu, Youhua (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)