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What is Tumor Suppressor Genes in Cancer Biology about?

Tumor suppressor genes (TSGs) play a critical role in DNA repair and maintaining genetic stability, with mutations in these genes leading to increased mutation rates and genetic instability in cancer cells. Key proteins like BRCA1 and BRCA2 are involved in repairing DNA double-strand breaks, while mutations affecting mitotic spindle behavior can result in chromosomal abnormalities such as aneuploidy. The spindle checkpoint mechanism, regulated by proteins like Mad and Bub, ensures proper chromosome attachme

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