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Stress–strain Behavior of Mitral Valve Leaflets in the Beating Ovine Heart by Gaurav Krishnamurthy; Akinobu Itoh; Wolfgang Bothe; Julia C. Swanson; Ellen Kuhl; Matts Karlsson; D. Craig Miller; Neil B. Ingels Jr. is a Medicine article available to read on EtoBox.

What is Stress–strain Behavior of Mitral Valve Leaflets in the Beating Ovine Heart about?

Excised anterior mitral leaflets exhibit anisotropic, non-linear material behavior with pre-transitional stiffness ranging from 0.06 to 0.09 N/mm 2 and post-transitional stiffness from 2 to 9 N/mm 2 . We used inverse finite element (FE) analysis to test, for the first time, whether the anterior mitral leaflet (AML), in vivo, exhibits similar non-linear behavior during isovolumic relaxation (IVR). Miniature radiopaque markers were sewn to the mitral annulus, AML, and papillary muscles in 8 sheep. Four-dimensional marker coordinates were obtained using biplane videofluoroscopic imaging during three consecutive cardiac cycles. A FE model of the AML was developed using marker coordinates at the end of isovolumic relaxation (when pressure difference across the valve is approximately zero), as the reference state. AML displacements were simulated during IVR using measured left ventricular and atrial pressures. AML elastic moduli in the radial and circumferential directions were obtained for each heartbeat by inverse FEA, minimizing the difference between simulated and measured displacements. Stress-strain curves for each beat were obtained from the FE model at incrementally increasing tr

Who reads Stress–strain Behavior of Mitral Valve Leaflets in the Beating Ovine Heart?

Author

Gaurav Krishnamurthy; Akinobu Itoh; Wolfgang Bothe; Julia C. Swanson; Ellen Kuhl; Matts Karlsson; D. Craig Miller; Neil B. Ingels Jr.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)

Published

2009

Language

EN

Field

Medicine (Health Sciences)