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Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models by Valeria Vasciaveo; Antonella Iadarola; Antonino Casile; Davide Dante; Giulia Morello; Lorenzo Minotta; Elena Tamagno; Alessandro Cicolin; Michela Guglielmotto is a Medicine article available to read on EtoBox.
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## Abstract Alzheimer’s disease (AD) is characterized by genetic and multifactorial risk factors. Many studies correlate AD to sleep disorders. In this study, we performed and validated a mouse model of AD and sleep fragmentation, which properly mimics a real condition of intermittent awakening. We noticed that sleep fragmentation induces a general acceleration of AD progression in 5xFAD mice, while in wild type mice it affects cognitive behaviors in particular learning and memory. Both these events may be correlated to aquaporin-4 (AQP4) modulation, a crucial player of the glymphatic system activity. In particular, sleep fragmentation differentially affects aquaporin-4 channel (AQP4) expression according to the stage of the disease, with an up-regulation in younger animals, while such change cannot be detected in older ones. Moreover, in wild type mice sleep fragmentation affects cognitive behaviors, in particular learning and memory, by compromising the glymphatic system through the decrease of AQP4. Nevertheless, an in-depth study is needed to better understand the mechanism by which AQP4 is modulated and whether it could be considered a risk factor for the disease development i
Who reads Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models?
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- Author
- Valeria Vasciaveo; Antonella Iadarola; Antonino Casile; Davide Dante; Giulia Morello; Lorenzo Minotta; Elena Tamagno; Alessandro Cicolin; Michela Guglielmotto
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)