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Is There a Relationship Between Solubility and Resorbability of Different Calcium Phosphate Phases in Vitro ? by Victoria M. Wu; Vuk Uskoković is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background: Does chemistry govern biology or it is the other way around - that is a broad connotation of the question that this study attempted to answer. ## Method: Comparison was made between the solubility and osteoclastic resorbability of four fundamentally different monophasic calcium phosphate (cp) powders with monodisperse particle size distributions: alkaline hydroxyapatite (hap), acidic monetite (dcp), β-calcium pyrophosphate (cpp), and amorphous cp (acp). results with the exception of cpp, the difference in solubility between different cp phases became neither mitigated nor reversed, but augmented in the resorptive osteoclastic milieu. thus, dcp, a phase with the highest solubility, was also resorbed more intensely than any other cp phase, whereas hap, a phase with the lowest solubility, was resorbed least. cpp becomes retained inside the cells for the longest period of time, indicating hindered digestion of only this particular type of cp. osteoclastogenesis was mildly hindered in the presence of hap, acp and dcp, but not in the presence of cpp. the most viable cp powder with respect to the mitochondrial succinic dehydrogenase activity was the one present in natural b

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Author

Victoria M. Wu; Vuk Uskoković

Publisher

Elsevier BV

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)