About this Medicine article

The influence of metronidazole resistance on the efficacy of ranitidine bismuth citrate triple therapy regimens for Helicobacter pylori infection by E. J. VAN DER WOUDEN; THIJS; A. A. VAN ZWET; KOOY; KLEIBEUKER is a Medicine article available to read on EtoBox.

## Aim : To assess the influence of metronidazole resistance on the efficacy of ranitidine bismuth citrate‐based triple therapy regimens in two consecutive studies. ## Methods : In the first study, patients with a culture‐proven __Helicobacter pylori__ infection were treated with ranitidine bismuth citrate 400 mg, metronidazole 500 mg, and clarithromycin 500 mg, all twice daily for 1 week (RMC). In the second study, amoxycillin 1000 mg was substituted for clarithromycin (RMA). Susceptibility testing for metronidazole was performed with the __E__‐test. Follow‐up endoscopy was performed after ≥ 4 weeks. Antral biopsy samples were taken for histology and urease test, and culture and corpus samples for histology and culture. ## Results : 112 patients, 53 males, age 55 ± 14 years (39 duodenal ulcer, 7 gastric ulcer and 66 gastritis) were treated with RMC, and 89 patients, 52 males, age 58 ± 15 years (23 duodenal ulcer, 7 gastric ulcer and 59 gastritis) were treated with RMA. For RMC, intention‐to‐treat eradication results were 98% (59/60, 95% CI: 91–100%) and 95% (20/21, 95% CI: 76–100%) for metronidazole susceptible and resistant strains, respectively (__P__= 0.45). For RMA these figur

Author

E. J. VAN DER WOUDEN; THIJS; A. A. VAN ZWET; KOOY; KLEIBEUKER

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

1999

Language

EN

Field

Medicine (Health Sciences)