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Theoretical Analysis of in Vivo Macrophage Adhesion and Foreign Body Giant Cell Formation on Strained Poly(etherurethane Urea) Elastomers by Weiyuan John Kao; Anne Hiltner; James M. Anderson; G. A. Lodoen is a Medicine article available to read on EtoBox.

What is Theoretical Analysis of in Vivo Macrophage Adhesion and Foreign Body Giant Cell Formation on Strained Poly(etherurethane Urea) Elastomers about?

Quantitative description of foreign body giant cell (FBGC) formation on poly(etherurethane urea) (PEUU) surfaces as a function of time can conceivably predict the effects of polymer characteristics on cellular responses in vim. In the present study, the formation of FBGCs on strained and unstrained PEUUs was quantified with two parameters: the density of adherent macrophages present initially that participate in FBGC formation (do) and the rate constant for cell fusion (k); both kinetic parameters were used to calculate the time-dependent FBGC density (dfc). Relationships were sought between results of the cellular analysis and the extent of environmental stress cracking (ESC), as characterized by scanning electron microscopy. Surface degradation was semiquantified with percent light transmittance. The materials used were: base PEUU, base PEUU with 1% Santowhitea antioxidant powder, base PEUU with 5% Methacrol 2138F@ antifume agent, and base PEUU with both 1% SantowhiteB and 5% Methacrol2138Fa. A compar-ison of unstrained base PEUU with base PEUU strained to 400% elongation indicated that the rate of cell fusion, but not do and dfc, increased in the presence of strain. In all strai

Who reads Theoretical Analysis of in Vivo Macrophage Adhesion and Foreign Body Giant Cell Formation on Strained Poly(etherurethane Urea) Elastomers?

Author

Weiyuan John Kao; Anne Hiltner; James M. Anderson; G. A. Lodoen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1994

Language

EN

Field

Medicine (Health Sciences)