Opening book details…
Can I read Gut Microbiome and Autism Spectrum Disorder on EtoBox?
Gut Microbiome and Autism Spectrum Disorder by Eleni Kotsiliti is a Medicine article available to read on EtoBox.
What is Gut Microbiome and Autism Spectrum Disorder about?
Maralixibat relieves chronic cholestasis in children Maralixibat is an apical sodium-dependent bile acid transport (ASBT) inhibitor that blocks enterohepatic recirculation of bile acids and could prolong transplant-free survival in children with chronic cholestasis due to Alagille syndrome. In ICONIC, a phase IIb placebo-controlled randomizedwithdrawal study, 31 children with Alagille syndrome received 380 μg/kg maralixibat once daily for 18 weeks. Of these, 29 children were randomly assigned to placebo or maralixibat for a further 4 weeks; the placebo-treated children experienced rising serum bile acid levels and worsening pruritus, which contrasted with sustained benefits in those who continued maralixibat. The 15 children who completed a 26-week open-label extension showed clinically meaningful improvements from baseline in serum bile acid levels, pruritus, xanthomas, height and quality of life. Maralixibat doses of up to 380 μg/kg twice daily were generally well tolerated. ASBT inhibitors could be an important treatment for cholestasis in Alagille syndrome.
Who reads Gut Microbiome and Autism Spectrum Disorder?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Eleni Kotsiliti
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)