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Phytochemical analysis, cytotoxic and antioxidant activities of Myrtus communis essential oil from Morocco by Younes Harassi; Mounir Tilaoui; Abderrazak Idir; Jullien Frédéric; Sylvie Baudino; Sana Ajouaoi; Hassan Ait Mouse; Abdelmajid Zyad is a Medicine article available to read on EtoBox.

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## Abstract ## Background __Myrtus communis__ L. is an aromatic evergreen plant common in Morocco. In addition to its culinary uses, it has been used medicinally as a disinfectant, an antiseptic or as a hypoglycemic agent. However, its cytotoxic activity has not been well investigated so far. The current study describes the chemical composition, cytotoxic and antioxidant activities of __Myrtus communis__ L essential oil obtained from different regions of Morocco. ## Methods __Myrtus communis__ essential oils were obtained by hydrodistillation, and analyzed by gas chromatography coupled with mass spectrometry. Cytotoxic activity was evaluated in murine mastocytoma P815 and MCF-7 breast cancer cells, using the MTT assay. In addition, DNA fragmentation was assessed by gel electrophoresis. The antioxidant effect was determined by measuring bleaching of β-carotene with the linoleic acid and the DPPH radical scavenging methods. ## Results GC-MS analysis showed high amounts of methyl eugenol (18.7%), α-terpineol (15.5%) and geranyl acetate (11.64%) in essential oil from the Benslimane region. In contrast, essential oil from Ouazzane was particularly rich in 1,8-cineole (36.3%). The cytoto

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Author
Younes Harassi; Mounir Tilaoui; Abderrazak Idir; Jullien Frédéric; Sylvie Baudino; Sana Ajouaoi; Hassan Ait Mouse; Abdelmajid Zyad
Publisher
Walter de Gruyter GmbH
Published
2019
Language
EN
Field
Medicine (Health Sciences)

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