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Public Health Issues Related to Infection in Pregnancy and Cerebral Palsy by Diana E. Schendel; Anne Schuchat; Poul Thorsen is a Medicine article available to read on EtoBox.

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## Abstract Cerebral palsy is the most common neuromotor developmental disability of childhood, affecting as many as 8,000 to 12,000 children born in the U.S. each year (corresponding to a prevalence rate of between 2 and 3 per 1000 children). Recent improvements in neonatal care have not resulted in a decline in the overall prevalence of cerebral palsy and, in fact, greater numbers of very preterm/very low birth weight infants are surviving with cerebral palsy and other developmental problems. Infection in pregnancy may be an important cause of the disorder. In preterm infants, there appears to be about a 2‐fold increased risk for cerebral palsy from chorioamnionitis, and in term infants the estimated increased risk is about 4‐fold. Provisionally, chorioamnionitis might account for 12% of spastic cerebral palsy in term infants and 28% of cerebral palsy in preterm infants. Studies of biochemical markers of fetal inflammation typically associated with infection also suggest that an inflammatory response may be an important independent etiologic factor. If a substantial proportion of cerebral palsy is attributable to acute amnionitis infection and/or neonatal sepsis, cerebral palsy s

Who reads Public Health Issues Related to Infection in Pregnancy and Cerebral Palsy?

Author

Diana E. Schendel; Anne Schuchat; Poul Thorsen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1080-4013)

Published

2002

Language

EN

Field

Medicine (Life Sciences)