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Therapeutic drug monitoring of meropenem and pharmacokinetic-pharmacodynamic target assessment in critically ill pediatric patients from a prospective observational study 1 1 Introduction 1 2 Materials and methods 2 2.1 Study design and settings 2 2.2 Meropenem dosing and administration 2 2.3 Blood sampling 2 2.4 Meropenem determination 2 2.5 Definitions 2 2.6 Sample size and statistical analysis 3 3 Results 3 3.1 Patient demographics 3 3.2 Meropenem plasma concentrations 3 3.3 Microbiological data 3 3.4 PK-PD indices achievement 3 3.5 Clinical outcomes 3 4 Discussion 3 Declaration of competing interests 6 Funding 6 Ethical approval 6 Acknowledgments 6 Author Contributions 6 References 6
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