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Can I read Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using ( S )-(−)-[^18^F]Fluspidine in Glioblastoma on EtoBox?
Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using ( S )-(−)-[^18^F]Fluspidine in Glioblastoma by Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; WÃ1⁄4nsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter is a Chemistry article available to read on EtoBox.
What is Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using ( S )-(−)-[^18^F]Fluspidine in Glioblastoma about?
Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of GBM. To test this hypothesis, we used the clinically applied sig1R-ligand (__S__)-(−)-[^18^F]fluspidine in imaging studies in an orthotopic mouse model of GBM (U87-MG) as well as in human GBM tissue. A tumour-specific overexpression of sig1R in the U87-MG model was revealed in vitro by autoradiography. The binding parameters demonstrated target-selective binding according to identical K~D~ values in the tumour area and the contralateral side, but a higher density of sig1R in the tumour. Different kinetic profiles were observed in both areas, with a slower washout in the tumour tissue compared to the contralateral side. The translational relevance of sig1R imaging in oncology is reflected by the autoradiographic detection of tumour-specific expression of sig1R in samples obtained from patie
Who reads Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using ( S )-(−)-[^18^F]Fluspidine in Glioblastoma?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; WÃ1⁄4nsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter
- Publisher
- Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Berlin: Springer, 1996-; Basel: 1997-; Springer Science and Business Media LLC (ISSN 1420-3049)
- Published
- 2020
- Language
- EN
- Field
- Chemistry (Life Sciences)