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Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7 by Tao Zuo; Peiru Chen; Sha Jing; Tao Zhang; Lei Chang; Feng Xu; Chao Zhao; Ping Xu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7 about?

As a hepadnavirus, hepatitis B virus (HBV) can cause damage to extrahepatic organs. The kidney is one of the organs that is more susceptible to damage. Research studies on HBV-associated glomerulonephritis (HBV-GN) have been going on for decades. However, the underlying molecular mechanism remains obscure. Here, we applied a tandem mass tag (TMT) isobaric labeling-based method to quantitatively profile the kidney proteome of HBV transgenic mice to illustrate the pathological mechanisms of HBV-GN. Weighted correlation network analysis, a clustering method for gene expression, is used to cluster proteins. Totally, we identified 127 proteins that were highly associated with HBV expression out of a total of 5169 quantified proteins. Among them, the downregulated solute carrier (SLC) family proteins are involved in the process of HBV-GN. We also found that IL1B was upregulated in the kidney tissue of HBV transgenic mice. These findings suggest that HBV disrupts the small molecule transport network of the kidney, which contributes to the occurrence of HBV-GN. The transporter, particularly SLC family 7 member 7 (SLC7A7), is involved in this process, which might serve as an intervention ta

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Author

Tao Zuo; Peiru Chen; Sha Jing; Tao Zhang; Lei Chang; Feng Xu; Chao Zhao; Ping Xu

Publisher

American Chemical Society; American Chemical Society (ACS) (ISSN 1535-3893)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)