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Mannosylated Polymeric Ligands for Targeted Delivery of Antibacterials and Their Adjuvants to Macrophages for the Enhancement of the Drug Efficiency by Igor D. Zlotnikov; Alexander A. Ezhov; Rostislav A. Petrov; Maksim A. Vigovskiy; Olga A. Grigorieva; Natalya G. Belogurova; Elena V. Kudryashova is a Medicine article available to read on EtoBox.
What is Mannosylated Polymeric Ligands for Targeted Delivery of Antibacterials and Their Adjuvants to Macrophages for the Enhancement of the Drug Efficiency about?
Bacterial infections and especially resistant strains of pathogens localized in macrophages and granulomas are intractable diseases that pose a threat to millions of people. In this paper, the theoretical and experimental foundations for solving this problem are proposed due to two key aspects. The first is the use of a three-component polymer system for delivering fluoroquinolones to macrophages due to high-affinity interaction with mannose receptors (CD206). Cytometry assay determined that 95.5% macrophage-like cells were FITC-positive after adding high-affine to CD206 trimannoside conjugate HPCD-PEI1.8-triMan, and 61.7% were FITC-positive after adding medium-affine ligand with linear mannose label HPCD-PEI1.8-Man. The second aspect is the use of adjuvants, which are synergists for antibiotics. Using FTIR and NMR spectroscopy, it was shown that molecular containers, namely mannosylated polyethyleneimines (PEIs) and cyclodextrins (CDs), load moxifloxacin (MF) with dissociation constants of the order of 10−4–10−6 M; moreover, due to prolonged release and adsorption on the cell membrane, they enhance the effect of MF. Using CLSM, it was shown that eugenol (EG) increases the penetrat
Who reads Mannosylated Polymeric Ligands for Targeted Delivery of Antibacterials and Their Adjuvants to Macrophages for the Enhancement of the Drug Efficiency?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Igor D. Zlotnikov; Alexander A. Ezhov; Rostislav A. Petrov; Maksim A. Vigovskiy; Olga A. Grigorieva; Natalya G. Belogurova; Elena V. Kudryashova
- Publisher
- MDPI AG
- Published
- 2022
- Language
- EN
- Field
- Medicine (Life Sciences)