Opening book details…
Can I read Gender Differences in Molecular‐guided Therapy Recommendations for Metastatic Malignant Mesothelioma on EtoBox?
Gender Differences in Molecular‐guided Therapy Recommendations for Metastatic Malignant Mesothelioma by Hossein Taghizadeh; Sabine Zöchbauer‐Müller; Robert M. Mader; Leonhard Müllauer; Thomas Klikovits; Thomas Bachleitner‐Hofmann; Mir A. Hoda; Gerald W. Prager is a Medicine article available to read on EtoBox.
What is Gender Differences in Molecular‐guided Therapy Recommendations for Metastatic Malignant Mesothelioma about?
## Abstract ## Background Malignant mesothelioma is an aggressive cancer and has a poor prognosis. Here, we analyzed the feasibility, molecular and gender aspects of targeted therapy recommendations for malignant mesothelioma based on the individual molecular tumor profile. ## Methods In this single‐center, real‐world retrospective analysis of our platform for precision medicine, we evaluated the molecular profiling of malignant mesothelioma in 14 patients, including nine men and five women. Tumor samples of the patients were examined with a 50 gene next‐generation sequencing (NGS) panel, immunohistochemistry, and fluorescence in situ hybridization, to detect possible molecular aberrations which may be targeted by off‐label therapy custom‐tailored to the individual patient. ## Results In total, we identified 11 mutations in six of the 14 patients, including __BAP1__, __FANCA__, __NF1__, __NF2__, __PD‐L1__, __RAD52D__, __SETD2__, __SRC__, and __TP53__. No mutation was detected in eight of the 14 patients. Targeted therapy was recommended for 11 out of the 14 patients. All recommendations were mainly based on the molecular characteristics determined by immunohistochemistry. Targeted
Who reads Gender Differences in Molecular‐guided Therapy Recommendations for Metastatic Malignant Mesothelioma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hossein Taghizadeh; Sabine Zöchbauer‐Müller; Robert M. Mader; Leonhard Müllauer; Thomas Klikovits; Thomas Bachleitner‐Hofmann; Mir A. Hoda; Gerald W. Prager
- Publisher
- Wiley
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)