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Molecular and Nanoparticulate Agents for Photodynamic Therapy Guided by Near Infrared Imaging by A. Grebinyk; O. Chepurna; M. Frohme; J. Qu; R. Patil; L.O. Vretik; T.Y. Ohulchanskyy is a Materials Science article available to read on EtoBox.

What is Molecular and Nanoparticulate Agents for Photodynamic Therapy Guided by Near Infrared Imaging about?

Photodynamic therapy (PDT) of cancer is a clinically approved, minimally invasive therapeutic approach, combining PDT drug (photosensitizer, PS), molecular oxygen and light to produce cytotoxicity via reactive oxygen species (ROS), which are generated by the light excited PS. Most of the PS molecules fluoresce under excitation with light and fluorescence imaging (FLI) can be employed to evaluate their biodistribution and assess the intratumoral delivery before the therapeutic light application. Light absorption can also be utilized to track a PS by photoacoustic imaging (PAI). However, an excitation of the PS during assessment of its biodistribution through FLI or PAI results in premature photobleaching and causes toxicity. An involvement of a separate fluorescent (luminescent) or photoacoustic imaging probe, which provides imaging contrast in combination with PS without excitation of the latter, can allow for "see-and-treat" approach with FLI/PAI guided PDT. On the other hand, it is well-known that near-infrared (NIR) light is able to penetrate relatively deeper in comparison with visible light, due to reduced absorption and scattering. In addition to the conventional NIR window (

Who reads Molecular and Nanoparticulate Agents for Photodynamic Therapy Guided by Near Infrared Imaging?

Author

A. Grebinyk; O. Chepurna; M. Frohme; J. Qu; R. Patil; L.O. Vretik; T.Y. Ohulchanskyy

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Materials Science (Physical Sciences)