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Ventilation/Perfusion Distribution Abnormalities In Morbidly Obese Subjects Before and After Bariatric Surgery by Eva Rivas; Ebymar Arismendi; Alvar Agustí; Marcelo Sanchez; Salvadora Delgado; Concepción Gistau; Peter D. Wagner; Roberto Rodriguez-Roisin is a Medicine article available to read on EtoBox.

What is Ventilation/Perfusion Distribution Abnormalities In Morbidly Obese Subjects Before and After Bariatric Surgery about?

## Background: Obesity is a global and growing public health problem. bariatric surgery (bs) is indicated in patients with morbid obesity. to our knowledge, the effects of morbid obesity and bs on ventilation/perfusion (v.a/q.) ratio distributions using the multiple inert gas elimination technique have never before been explored. ## Methods: We compared respiratory and inert gas (v.a/q. ratio distributions) pulmonary gas exchange, breathing both ambient air and 100% oxygen, in 19 morbidly obese women (bmi, 45 kg/m2), both before and 1 year after bs, and in eight normal-weight, never smoker, age-matched, healthy women. ## Results: Before bs, morbidly obese individuals had reduced arterial po2 (76 ± 2 mm hg) and an increased alveolar-arterial po2 difference (27 ± 2 mm hg) caused by small amounts of shunt (4.3% ± 1.1% of cardiac output), along with abnormally broadly unimodal blood flow dispersion (0.83 ± 0.06). during 100% oxygen breathing, shunt increased twofold in parallel with a reduction of blood flow to low v.a/q. units, suggesting the development of reabsorption atelectasis without reversion of hypoxic pulmonary vasoconstriction. after bs, body weight was reduced significantly

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Author

Eva Rivas; Ebymar Arismendi; Alvar Agustí; Marcelo Sanchez; Salvadora Delgado; Concepción Gistau; Peter D. Wagner; Roberto Rodriguez-Roisin

Publisher

Elsevier BV

Published

2014

Language

EN

Field

Medicine (Health Sciences)