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Serum levels of carboxyterminal cross‐linked telopeptide of type I collagen (ICTP) in the differential diagnosis of the syndromes of inappropriate secretion of TSH by L. Persani; D. Preziati; C. H. Matthews; A. Sartorio; V. K. K. Chatterjee; P. Beck‐Peccoz is a Medicine article available to read on EtoBox.
What is Serum levels of carboxyterminal cross‐linked telopeptide of type I collagen (ICTP) in the differential diagnosis of the syndromes of inappropriate secretion of TSH about?
## BACKGROUND AND OBJECTIVE Serum TSH assay is a very sensitive and specific index of thyroid hormone (TH) action. Nevertheless, in particular clinical situations, such as those of inappropriate TSH secretion, the measurement of additional parameters evaluating peripheral TH action may be required in order to achieve a correct diagnosis and to assess the impact that thyroid hormone have on a given tissue. The availability of a specific RIA for serum carboxyterminal cross‐linked telopeptide of type I collagen (ICTP) prompted us to study the usefulness of this specific marker of bone resorption in the differential diagnosis of thyroid disorders. ## DESIGN Serum ICTP levels were measured in: (a) 10 patients with TSH‐secreting pituitary adenoma (TSH‐oma), (b) 40 with thyroid hormone resistance (RTH), as well as in (c) 28 patients with Graves' disease or toxic nodular goitre, (d) 31 with autoimmune primary hypothyroidism (PH) and in 8 of them during L‐T4 replacement therapy, (e) 23 with central hypothyroidsim (CH) during L‐T4 therapy and 2 months after its withdrawal, and (f) 26 during TSH‐suppressive treatment for goitre or non‐metastatic differentiated thyroid cancer. Results were com
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- Author
- L. Persani; D. Preziati; C. H. Matthews; A. Sartorio; V. K. K. Chatterjee; P. Beck‐Peccoz
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)