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Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors by Maria Cristina Mingari; Gabriella Pietra; Lorenzo Moretta is a Immunology and Microbiology article available to read on EtoBox.

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MHC class-1-specific inhibitory receptors were originally described in NK cells, in which they represent an important fail-safe mechanism that induces NK cell tolerance to normal self cells. These inhibitory NK receptors (iNKRs) were subsequently found expressed on different T cell subsets, primarily CD8(+) cytolytic T lymphocytes (CTLs), in which they can inhibit T cell receptor mediated functions. Some iNKR(+) CTLs are HLA-E-restricted, represent oligo- or monoclonal expansions, and can play a defensive role in viral infections. Although T cell activation, in the presence of certain cytokines, can induce the expression of the CD94-NKG2A heterodimeric receptor, the mechanism leading to the expression of killer immunoglobulin-like receptors (KIRs) is still unknown. The expression of iNKRs in T cells might contribute to the prevention of apoptotic cell death, thus allowing their survival and clonal expansion in vivo. In addition, iNKR(+) T cells might contribute to peripheral self-tolerance.

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Author

Maria Cristina Mingari; Gabriella Pietra; Lorenzo Moretta

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0952-7915)

Published

2005

Language

EN

Field

Immunology and Microbiology (Life Sciences)