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Can I read Evaluation of Bioadhesive Gels for Local Action in the Esophagus on EtoBox?
Evaluation of Bioadhesive Gels for Local Action in the Esophagus by Laxmi Shanthi Chede; Maureen D. Donovan is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Evaluation of Bioadhesive Gels for Local Action in the Esophagus about?
Direct drug administration to the esophagus faces several obstacles, including continuous salivary dilution and removal of the dosage form from the tissue surface due to esophageal peristalsis. These actions often result in short exposure times and reduced concentrations of drug at the esophageal surface, providing limited opportunities for drug absorption into or across the esophageal mucosa. A variety of bioadhesive polymers were investigated for their ability to resist removal by salivary washings using an ex vivo porcine esophageal tissue model. Hydroxypropylmethylcellulose and carboxymethylcellulose both have reported bioadhesive properties, but neither was able to withstand repeated exposure to saliva, and the gels formulated with these polymers were quickly removed from the esophageal surface. Two polyacrylic polymers, carbomer and polycarbophil, also showed limited esophageal surface retention when exposed to salivary washing, likely due to the ionic composition of saliva affecting the inter-polymer interactions necessary for these polymers to maintain their increased viscosities. In situ gel forming polysaccharide gels (ion-triggered), including xanthan gum, gellan gum, an
Who reads Evaluation of Bioadhesive Gels for Local Action in the Esophagus?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Laxmi Shanthi Chede; Maureen D. Donovan
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)