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Comparative transcriptome profiling reveals a mechanism of Streptococcus agalactiae resistance to florfenicol by Ze Zhang; Yuhui Li; Minqiang Hu; Angen Yu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Florfenicol is widely used to control diseases in aquatic animals, and is used extensively to treat streptococcosis-caused by Streptococcus agalactiae-in the commercially important fish tilapia. There are known issues with the development of florfenicol resistance in Streptococcus agalactiae, but the underlying resistance mechanisms are not clear, a situation currently preventing optimal deployment of antibiotics. Here, we examined the induction of resistance by successively increasing the concentrations of florfenicol, and then used RNA-sequencing (RNA-Seq) to characterize changes in the transcriptomes of a florfenicol-resistant strain (H51-R) and a florfenicol-sensitive strain (H51-S). We obtained a total of 18,418,068 sequence reads in H51-R and 16,070,122 sequence reads in H51-S, from which a total of 1940 unigenes were assembled. In total, 376 unigenes were found to be differently expressed genes (DEGs). After florfenicol treatment, 181 genes were upregulated and 195 genes were downregulated. GO functional analysis of the DEGs indicated that the most strongly enriched GO terms included metabolic process (152 genes), catalytic activity (146), and binding (133), with terms inclu

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Author

Ze Zhang; Yuhui Li; Minqiang Hu; Angen Yu

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0882-4010)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)