Opening book details…
Can I read Prevalence of Clozapine-induced Sialorrhea and Its Effect on Quality of Life on EtoBox?
Prevalence of Clozapine-induced Sialorrhea and Its Effect on Quality of Life by D. Sanagustin; M. Martin-Subero; B. Hogg; L. Fortea; I. Gardoki; D. Guinart; M. Roldán; M. Angelats; L. Cerro; D. Navas; J. D. Jiménez; L. Ortiz; R. Ros; X. Polo; Y. Ventura; J. Contreras; A. Moreno-Alcázar; V. Pérez-Sola; B. L. Amann; A. Valiente-Gómez is a Neuroscience article available to read on EtoBox.
What is Prevalence of Clozapine-induced Sialorrhea and Its Effect on Quality of Life about?
Rationale Clozapine has proven to be superior to other antipsychotic drugs in the treatment of schizophrenia but is underprescribed due to its potentially severe side effects. Clozapine-induced sialorrhea (CIS) is a frequent and extremely uncomfortable side effect, which remains understudied. Objectives To examine the prevalence of diurnal and nocturnal CIS in a sample of patients treated with clozapine, and to evaluate its impact on quality of life. Methods We conducted a cross-sectional, observational study of 130 patients with schizophrenia spectrum disorders treated with clozapine. The prevalence of CIS was evaluated via specific sialorrhea scales. None of the patients included in the study was receiving a specific treatment for hypersalivation during the study period. Possible associations between sialorrhea and clinical and quality of life variables were analyzed. Results Of 130 subjects, 120 (92.3%) suffered from CIS. Eighty-one (62.31%) suffered from diurnal CIS, 115 (88.56%) from nocturnal CIS, and 85 (65.38%) suffered from both. Significant positive associations between quality of life and diurnal CIS (B = 0.417; p = 2.1e -6, R 2 = 0.156) and nocturnal CIS (B = 0.411; p =
Who reads Prevalence of Clozapine-induced Sialorrhea and Its Effect on Quality of Life?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- D. Sanagustin; M. Martin-Subero; B. Hogg; L. Fortea; I. Gardoki; D. Guinart; M. Roldán; M. Angelats; L. Cerro; D. Navas; J. D. Jiménez; L. Ortiz; R. Ros; X. Polo; Y. Ventura; J. Contreras; A. Moreno-Alcázar; V. Pérez-Sola; B. L. Amann; A. Valiente-Gómez
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)