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β ‐Cyclodextrin hydrogel incorporating hydrophobically modified poly( N ‐isopropylacrylamide) for a temperature‐dependent release by Mi Sun Lee; Jin‐Chul Kim is a Materials Science article available to read on EtoBox.

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## Abstract Hydrogels exhibiting a temperature‐dependent release were prepared by incorporating hydrophobically modified poly(__N__‐isopropylacrylamide) (HmPNIPAM) into __β__‐cyclodextrin hydrogels (__β__‐CD hydrogels). The specific loading of HmPNIPAM was about 0.0069 g HmPNIPAM/g __β__‐CD hydrogels. The incorporation of the polymer was qualitatively conformed by FT‐IR spectroscopy and SEM. The percent release of blue dextran in 24 hr at 20°C (about 77%) was markedly higher than those obtained at 35°C and 45°C (about 53 and 55%, respectively). At the higher temperatures, the volume of the hydrogel could decrease upon the thermal contraction of HmPNIPAM, leading to a smaller mesh and a suppressed release. In fact, the swelling ratio in 24 hr at 35°C and 45°C (about 396% and 405%, respectively) was obviously lower than that obtained at 20°C (about 465%). Copyright © 2011 John Wiley & Sons, Ltd.

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Author
Mi Sun Lee; Jin‐Chul Kim
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1042-7147)
Published
2011
Language
EN
Field
Materials Science (Physical Sciences)

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