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This study investigates the development of a hydroxyapatite/collagen (HA/Col) nanocomposite as a medical device for bone fusion and defect repair. The effects of cross-linking and the presence of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the mechanical properties and bioresorbability of the composite were examined through experiments on beagle dogs. Results indicate that cross-linking enhances mechanical strength and bioresorbability, making the HA/Col composite a promising alternative for

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collagen.jmd

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EN